diff --git a/src/cmd/compile/internal/noder/reader.go b/src/cmd/compile/internal/noder/reader.go
index 0440d324cc..635f02630f 100644
--- a/src/cmd/compile/internal/noder/reader.go
+++ b/src/cmd/compile/internal/noder/reader.go
@@ -2468,6 +2468,15 @@ func finishWrapperFunc(fn *ir.Func, target *ir.Package) {
 	// so we're responsible for applying inlining ourselves here.
 	inline.InlineCalls(fn)
 
+	// The body of wrapper function after inlining may reveal new ir.OMETHVALUE node,
+	// we don't know whether wrapper function has been generated for it or not, so
+	// generate one immediately here.
+	ir.VisitList(fn.Body, func(n ir.Node) {
+		if n, ok := n.(*ir.SelectorExpr); ok && n.Op() == ir.OMETHVALUE {
+			wrapMethodValue(n.X.Type(), n.Selection, target, true)
+		}
+	})
+
 	target.Decls = append(target.Decls, fn)
 }
 
diff --git a/test/fixedbugs/issue52128.dir/a.go b/test/fixedbugs/issue52128.dir/a.go
new file mode 100644
index 0000000000..0abf831c6f
--- /dev/null
+++ b/test/fixedbugs/issue52128.dir/a.go
@@ -0,0 +1,21 @@
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package a
+
+type I interface{}
+
+type F func()
+
+type s struct {
+	f F
+}
+
+func NewWithF(f F) *s {
+	return &s{f: f}
+}
+
+func NewWithFuncI(func() I) *s {
+	return &s{}
+}
diff --git a/test/fixedbugs/issue52128.dir/b.go b/test/fixedbugs/issue52128.dir/b.go
new file mode 100644
index 0000000000..86f6ed7e05
--- /dev/null
+++ b/test/fixedbugs/issue52128.dir/b.go
@@ -0,0 +1,17 @@
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package b
+
+import (
+	"./a"
+)
+
+type S struct{}
+
+func (s *S) M1() a.I {
+	return a.NewWithF(s.M2)
+}
+
+func (s *S) M2() {}
diff --git a/test/fixedbugs/issue52128.dir/p.go b/test/fixedbugs/issue52128.dir/p.go
new file mode 100644
index 0000000000..d3f3dbbfb9
--- /dev/null
+++ b/test/fixedbugs/issue52128.dir/p.go
@@ -0,0 +1,14 @@
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package p
+
+import (
+	"./a"
+	"./b"
+)
+
+func f() {
+	a.NewWithFuncI((&b.S{}).M1)
+}
diff --git a/test/fixedbugs/issue52128.go b/test/fixedbugs/issue52128.go
new file mode 100644
index 0000000000..8bb5c3e213
--- /dev/null
+++ b/test/fixedbugs/issue52128.go
@@ -0,0 +1,7 @@
+// compiledir
+
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package ignored