diff --git a/src/cmd/compile/internal/walk/closure.go b/src/cmd/compile/internal/walk/closure.go
index 68e16803be..f7bd2e0e07 100644
--- a/src/cmd/compile/internal/walk/closure.go
+++ b/src/cmd/compile/internal/walk/closure.go
@@ -235,15 +235,7 @@ func methodValueWrapper(dot *ir.SelectorExpr) *ir.Name {
 	saveLineNo := base.Pos
 	ir.CurFunc = nil
 
-	// Set line number equal to the line number where the method is declared.
-	if pos := dot.Selection.Pos; pos.IsKnown() {
-		base.Pos = pos
-	}
-	// Note: !dot.Selection.Pos.IsKnown() happens for method expressions where
-	// the method is implicitly declared. The Error method of the
-	// built-in error type is one such method.  We leave the line
-	// number at the use of the method expression in this
-	// case. See issue 29389.
+	base.Pos = base.AutogeneratedPos
 
 	tfn := ir.NewFuncType(base.Pos, nil,
 		typecheck.NewFuncParams(t0.Params(), true),
diff --git a/test/fixedbugs/issue51401.go b/test/fixedbugs/issue51401.go
new file mode 100644
index 0000000000..1e8e0d0b6e
--- /dev/null
+++ b/test/fixedbugs/issue51401.go
@@ -0,0 +1,44 @@
+// run
+
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Issue 51401: bad inline info in generated interface method wrapper
+// causes infinite loop in stack unwinding.
+
+package main
+
+import "runtime"
+
+type Outer interface{ Inner }
+
+type impl struct{}
+
+func New() Outer { return &impl{} }
+
+type Inner interface {
+	DoStuff() error
+}
+
+func (a *impl) DoStuff() error {
+	return newError()
+}
+
+func newError() error {
+	stack := make([]uintptr, 50)
+	runtime.Callers(2, stack[:])
+
+	return nil
+}
+
+func main() {
+	funcs := listFuncs(New())
+	for _, f := range funcs {
+		f()
+	}
+}
+
+func listFuncs(outer Outer) []func() error {
+	return []func() error{outer.DoStuff}
+}