diff --git a/test/run.go b/test/run.go
index 6339095d95..869911a426 100644
--- a/test/run.go
+++ b/test/run.go
@@ -1999,7 +1999,8 @@ var types2Failures32Bit = setOf(
 )
 
 var g3Failures = setOf(
-	"typeparam/nested.go", // -G=3 doesn't support function-local types with generics
+	"typeparam/nested.go",     // -G=3 doesn't support function-local types with generics
+	"typeparam/issue51521.go", // -G=3 produces bad panic message and link error
 )
 
 // In all of these cases, -G=0 reports reasonable errors, but either -G=0 or types2
diff --git a/test/typeparam/issue51521.go b/test/typeparam/issue51521.go
new file mode 100644
index 0000000000..5eb4e35c18
--- /dev/null
+++ b/test/typeparam/issue51521.go
@@ -0,0 +1,30 @@
+// run
+
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package main
+
+import (
+	"fmt"
+	"strings"
+)
+
+type I interface{ M() }
+
+func F[P I](p P) { defer catch(); p.M() }
+func G[T any]()  { defer catch(); interface{ M() T }.M(nil) }
+
+func main() {
+	F[I](nil)
+	G[int]()
+}
+
+func catch() {
+	err := recover()
+	if err, ok := err.(error); ok && strings.Contains(err.Error(), "nil pointer dereference") {
+		return
+	}
+	fmt.Println("FAIL", err)
+}