diff --git a/src/cmd/compile/internal/walk/complit.go b/src/cmd/compile/internal/walk/complit.go
index abd920d646..1f288d21c1 100644
--- a/src/cmd/compile/internal/walk/complit.go
+++ b/src/cmd/compile/internal/walk/complit.go
@@ -621,6 +621,12 @@ func oaslit(n *ir.AssignStmt, init *ir.Nodes) bool {
 		// not a special composite literal assignment
 		return false
 	}
+	if x.Addrtaken() {
+		// If x is address-taken, the RHS may (implicitly) uses LHS.
+		// Not safe to do a special composite literal assignment
+		// (which may expand to multiple assignments).
+		return false
+	}
 
 	switch n.Y.Op() {
 	default:
@@ -629,7 +635,7 @@ func oaslit(n *ir.AssignStmt, init *ir.Nodes) bool {
 
 	case ir.OSTRUCTLIT, ir.OARRAYLIT, ir.OSLICELIT, ir.OMAPLIT:
 		if ir.Any(n.Y, func(y ir.Node) bool { return ir.Uses(y, x) }) {
-			// not a special composite literal assignment
+			// not safe to do a special composite literal assignment if RHS uses LHS.
 			return false
 		}
 		anylit(n.Y, n.X, init)
diff --git a/test/fixedbugs/issue52953.go b/test/fixedbugs/issue52953.go
new file mode 100644
index 0000000000..2085e4e3fe
--- /dev/null
+++ b/test/fixedbugs/issue52953.go
@@ -0,0 +1,29 @@
+// run
+
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Issue 52953: miscompilation for composite literal assignment
+// when LHS is address-taken.
+
+package main
+
+type T struct {
+	Field1 bool
+}
+
+func main() {
+	var ret T
+	ret.Field1 = true
+	var v *bool = &ret.Field1
+	ret = T{Field1: *v}
+	check(ret.Field1)
+}
+
+//go:noinline
+func check(b bool) {
+	if !b {
+		panic("FAIL")
+	}
+}